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Laminin-10 is crucial for hair morphogenesis.

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The EMBO journal 📖 저널 OA 99.1% 2021: 2/2 OA 2022: 1/1 OA 2023: 13/13 OA 2024: 8/8 OA 2025: 28/28 OA 2026: 25/26 OA 2021~2026 2003 Vol.22(10) p. 2400-10 피인용 8회 cited 159 OA RCR 2.32 Hair Growth and Disorders
TL;DR The essential role of laminin‐10 (α5β1γ1) in hair follicle development is described and the first use of exogenous protein to correct a cutaneous developmental defect is reported, marking a first in the literature.
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PubMed DOI PMC OpenAlex Semantic 마지막 보강 2026-05-10
📑 코퍼스 인용 관계 · 인용됨 8
📑 인용한 논문 (6) ▾
연도별 인용 (2012–2025) · 합계 75
OpenAlex 토픽 · Hair Growth and Disorders Skin and Cellular Biology Research Wnt/β-catenin signaling in development and cancer

Li J, Tzu J, Chen Y, Zhang YP, Nguyen NT, Gao J

📖 무료 전문 🟢 PMC 전문 PMC155997 🔓 OA PDF oa
PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

Abstract

The role of the extracellular matrix in cutaneous morphogenesis is poorly understood. Here, we describe the essential role of laminin-10 (alpha5beta1gamma1) in hair follicle development. Laminin-10 was present in the basement membrane of elongating hair germs, when other laminins were downregulated, suggesting a role for laminin-10 in hair development. Treatment of human scalp xenografts with antibodies to laminin-10, or its receptor beta1 integrin, produced alopecia. E16.5 Lama5 -/- mouse skin, lacking laminin-10, contained fewer hair germs compared with controls, and after transplantation, Lama5 -/- skin showed a failure of hair germ elongation followed by complete hair follicle regression. Lama5 -/- skin showed defective basement membrane assembly, without measurable increases in anoikis. Instead, Lama5 -/- skin showed decreased expression of early hair markers including sonic hedgehog and Gli1, implicating laminin-10 in developmental signaling. Intriguingly, treatment of Lama5 -/- skin with purified laminin-10 corrected basement membrane defects and restored hair follicle development. We conclude that laminin-10 is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect.
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The essential role of laminin‐10 (α5β1γ1) in hair follicle development is described and the first use of exogenous protein to correct a cutaneous developmental defect is reported, marking a first in t

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↓ .bib ↓ .ris
APA 7 Li, J., Tzu, J., Chen, Y., Zhang, Y. P., Nguyen, N. T., Gao, J., Bradley, M., Keene, D. R., Oro, A. E., Miner, J. H., & Marinkovich, M. P. (2003). Laminin-10 is crucial for hair morphogenesis.. The EMBO journal, 22(10), 2400-10. https://doi.org/10.1093/emboj/cdg239
Vancouver Li J, Tzu J, Chen Y, Zhang YP, Nguyen NT, Gao J, et al. Laminin-10 is crucial for hair morphogenesis. The EMBO journal. 2003;22(10):2400-10. doi:10.1093/emboj/cdg239
AMA 11 Li J, Tzu J, Chen Y, Zhang YP, Nguyen NT, Gao J, et al. Laminin-10 is crucial for hair morphogenesis. The EMBO journal. 2003;22(10):2400-10. doi:10.1093/emboj/cdg239
Chicago Li, J., Tzu, J., Chen, Y., Zhang, Y. P., Nguyen, N. T., Gao, J., Bradley, M., Keene, D. R., Oro, A. E., Miner, J. H., and .... 2003. "Laminin-10 is crucial for hair morphogenesis." The EMBO journal 22 (10): 2400-10. https://doi.org/10.1093/emboj/cdg239
MLA 9 Li, J., et al. "Laminin-10 is crucial for hair morphogenesis." The EMBO journal, vol. 22, no. 10, 2003, pp. 2400-10. doi:10.1093/emboj/cdg239.
PMID 12743034 ↗
DOI 10.1093/emboj/cdg239

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

인용 관계

그래프 OA 노드: 8/8 (100%) · 참조 0편 · 후속 8편

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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반

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