Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype.

Stephen Lyle; David E. Elder; Melpo Christofidou‐Solomidou; Yaping Liu; Steven Μ. Albelda; George Cotsarelis

doi:10.1038/sj.jidsp.5640233

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Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype.

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4/5 보강

The journal of investigative dermatology. Symposium proceedings 📖 저널 OA 96% 1999 Vol.4(3) p. 296-301 피인용 5회 cited 133 OA RCR 2.27 Hair Growth and Disorders

TL;DR It is shown that the C8/144B monoclonal antibody, originally raised against a CD8 peptide sequence, immunostains the human hair follicle bulge and that K15-positive bulge cells possess a stem cell phenotype characterized by their slowly cycling nature, proliferation at the onset of new hair follicles growth, and high level of beta1 integrin expression.

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OpenAlex 토픽 · Hair Growth and Disorders

Lyle S, Christofidou-Solomidou M, Liu Y, Elder DE, Albelda S, Cotsarelis G

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It is shown that the C8/144B monoclonal antibody, originally raised against a CD8 peptide sequence, immunostains the human hair follicle bulge and that K15-positive bulge cells possess a stem cell phe

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APA Stephen Lyle, David E. Elder, et al. (1999). Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype.. The journal of investigative dermatology. Symposium proceedings, 4(3), 296-301. https://doi.org/10.1038/sj.jidsp.5640233

MLA Stephen Lyle, et al.. "Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype.." The journal of investigative dermatology. Symposium proceedings, vol. 4, no. 3, 1999, pp. 296-301.

PMID 10674385 ↗

DOI 10.1038/sj.jidsp.5640233

Abstract

Stem cells are vital for the homeostasis of self-renewing tissues and their manipulation may have wide ranging applications, including gene therapy, wound repair, and tissue transplantation. Although rodent hair follicle stem cells have been localized to the follicle bulge, the location of human hair follicle stem cells is less clear, and their characterization has been hampered by a lack of cellular markers for the bulge area. We demonstrate that the C8/144B monoclonal antibody, originally raised against a CD8 peptide sequence, immunostains the human hair follicle bulge. We show that this antibody recognizes cytokeratin 15 (K15) in keratinocytes, and that K15-positive bulge cells possess a stem cell phenotype characterized by their slowly cycling nature, proliferation at the onset of new hair follicle growth, and high level of beta1 integrin expression. These results localize human hair follicle stem cells to the bulge and suggest that K15 is preferentially expressed in epithelial stem cells.

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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그래프 OA 노드: 4/5 (80%) · 참조 0편 · 후속 4편

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Abstract 한글 요약

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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Abstract