The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells.
💡 한 문장 핵심
C8/144B 단클론항체는 cytokeratin 15를 인식하며 인체 모낭 줄기세포의 위치를 규명한다.
4/5 보강
TL;DR
It is demonstrated that bulge cells possess a stem cell phenotype characterized by their slowly-cycling nature, preferential proliferation at the onset of new hair follicle growth, high level of beta1 integrin expression, and expression of cytokeratin 19.
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· 인용됨 27
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연도별 인용 (2012–2026) · 합계 230
OpenAlex 토픽 ·
Skin and Cellular Biology Research
Hair Growth and Disorders
Proteoglycans and glycosaminoglycans research
Abstract 🌐 Abstract
Stem cells are vital for the homeostasis of self-renewing tissues such as the hair follicle. Epithelial stem cells have been implicated in tumorigenesis and wound healing, and their manipulation may have wide ranging applications including gene therapy and tissue transplantation. Rodent hair follicle stem cells have been localized to an area of the follicle called the bulge, however, the identification and characterization of human hair follicle stem cells has been hampered by a lack of cellular markers for this area. We have determined that the C8/144B monoclonal antibody, originally generated against a short intracytoplasmic peptide of CD8, preferentially immunostains hair follicle bulge keratinocytes without staining the remaining hair follicle. Using expression cloning, we identified cytokeratin 15 as the keratinocyte protein recognized by the C8/144B monoclonal antibody. By delineating the bulge using this antibody, we demonstrated that bulge cells possess a stem cell phenotype characterized by their slowly-cycling nature, preferential proliferation at the onset of new hair follicle growth, high level of beta1 integrin expression, and expression of cytokeratin 19.
It is demonstrated that bulge cells possess a stem cell phenotype characterized by their slowly-cycling nature, preferential proliferation at the onset of new hair follicle growth, high level of beta1
APA 7
Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D. E., Albelda, S., & Cotsarelis, G. (1998). The c8/144b monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells.. Journal of cell science, 111 ( Pt 21), 3179-88. https://doi.org/10.1242/jcs.111.21.3179
Vancouver
Lyle S, Christofidou-Solomidou M, Liu Y, Elder DE, Albelda S, Cotsarelis G. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. Journal of cell science. 1998;111 ( Pt 21):3179-88. doi:10.1242/jcs.111.21.3179
AMA 11
Lyle S, Christofidou-Solomidou M, Liu Y, Elder DE, Albelda S, Cotsarelis G. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. Journal of cell science. 1998;111 ( Pt 21):3179-88. doi:10.1242/jcs.111.21.3179
Chicago
Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D. E., Albelda, S., and Cotsarelis, G.. 1998. "The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells." Journal of cell science 111 ( Pt 21): 3179-88. https://doi.org/10.1242/jcs.111.21.3179
MLA 9
Lyle, S., et al. "The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells." Journal of cell science, vol. 111 ( Pt 21), 1998, pp. 3179-88. doi:10.1242/jcs.111.21.3179.
PMID
9763512 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
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