Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle.
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TL;DR
It is shown that sonic hedgehog (shh)-/- mouse embryos have disrupted formation of dermal papillae, and expression patterns and mutant phenotypes suggest that epidermal PDGF-A has a role in stimulating the proliferation ofDermal mesenchymal cells that may contribute to the formation of Dermal papilla, mesenchylal sheaths and dermal fibroblasts.
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연도별 인용 (2012–2026) · 합계 123
OpenAlex 토픽 ·
Hair Growth and Disorders
Cancer and Skin Lesions
Skin and Cellular Biology Research
Abstract 🌐 Abstract
Skin appendages, such as hair, develop as a result of complex reciprocal signaling between epithelial and mesenchymal cells. These interactions are not well understood at the molecular level. Platelet-derived growth factor-A (PDGF-A) is expressed in the developing epidermis and hair follicle epithelium, and its receptor PDGF-Ralpha is expressed in associated mesenchymal structures. Here we have characterized the skin and hair phenotypes of mice carrying a null mutation in the PDGF-A gene. Postnatal PDGF-A-/- mice developed thinner dermis, misshapen hair follicles, smaller dermal papillae, abnormal dermal sheaths and thinner hair, compared with wild-type siblings. BrdU labeling showed reduced cell proliferation in the dermis and in the dermal sheaths of PDGF-A-/- skin. PDGF-A-/- skin transplantation to nude mice led to abnormal hair formation, reproducing some of the features of the skin phenotype of PDGF-A-/- mice. Taken together, expression patterns and mutant phenotypes suggest that epidermal PDGF-A has a role in stimulating the proliferation of dermal mesenchymal cells that may contribute to the formation of dermal papillae, mesenchymal sheaths and dermal fibroblasts. Finally, we show that sonic hedgehog (shh)-/- mouse embryos have disrupted formation of dermal papillae. Such embryos fail to form pre-papilla aggregates of postmitotic PDGF-Ralpha-positive cells, suggesting that shh has a critical role in the assembly of the dermal papilla.
It is shown that sonic hedgehog (shh)-/- mouse embryos have disrupted formation of dermal papillae, and expression patterns and mutant phenotypes suggest that epidermal PDGF-A has a role in stimulatin
APA 7
Karlsson, L., Bondjers, C., & Betsholtz, C. (1999). Roles for pdgf-a and sonic hedgehog in development of mesenchymal components of the hair follicle.. Development (Cambridge, England), 126(12), 2611-21. https://doi.org/10.1242/dev.126.12.2611
Vancouver
Karlsson L, Bondjers C, Betsholtz C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Deve. (Cam. Engl.. 1999;126(12):2611-21. doi:10.1242/dev.126.12.2611
AMA 11
Karlsson L, Bondjers C, Betsholtz C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Deve. (Cam. Engl.. 1999;126(12):2611-21. doi:10.1242/dev.126.12.2611
Chicago
Karlsson, L., Bondjers, C., and Betsholtz, C.. 1999. "Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle." Development (Cambridge, England) 126 (12): 2611-21. https://doi.org/10.1242/dev.126.12.2611
MLA 9
Karlsson, L., et al. "Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle." Development (Cambridge, England), vol. 126, no. 12, 1999, pp. 2611-21. doi:10.1242/dev.126.12.2611.
PMID
10331973 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Actins
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins
- Cell Division
- Dermis
- Embryonic Induction
- Gene Expression Regulation
- Developmental
- Hair Follicle
- Hedgehog Proteins
- Male
- Membrane Proteins
- Mesoderm
- Mice
- Inbred BALB C
- Inbred Strains
- Mutant Strains
- Nude
- Muscle
- Smooth
- Patched Receptors
- Platelet-Derived Growth Factor
… 외 9개
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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