Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells.
💡 한 문장 핵심
Minoxidil은 인간 모발 모유두세포에서 vascular endothelial growth factor의 발현을 상향 조절한다.
4/5 보강
TL;DR
Two studies support the hypothesis that minoxidil has a physiological role in maintaining a good vascularization of hair follicles in androgenetic alopecia and VEGF protein production increases in cell extracts and conditioned media following minxidil stimulation.
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· 인용됨 64
📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 209
OpenAlex 토픽 ·
Hair Growth and Disorders
Dermatologic Treatments and Research
melanin and skin pigmentation
Abstract 🌐 Abstract
The hair follicle dermal papilla which controls hair growth, is characterized in the anagen phase by a highly developed vascular network. We have demonstrated in a previous study that the expression of an angiogenic growth factor called vascular endothelial growth factor (VEGF) mRNA varied during the hair cycle. VEGF mRNA is strongly expressed in dermal papilla cells (DPC) in the anagen phase, but during the catagen and telogen phases. VEGF mRNA is less strongly expressed. This involvement of VEGF during the hair cycle allowed us to determine whether VEGF mRNA expression by DPC was regulated by minoxidil. In addition, the effect of minoxidil on VEGF protein synthesis in both cell extracts and DPC-conditioned medium, was investigated immunoenzymatically. Both VEGF mRNA and protein were significantly elevated in treated DPC compared with controls. DPC incubated with increasing minoxidil concentrations (0.2, 2, 6, 12 and 24 mumol/L) induced a dose-dependent expression of VEGF mRNA. Quantification of transcripts showed that DPC stimulated with 24 mumol/L minoxidil express six times more VEGF mRNA than controls. Similarly, VEGF protein production increases in cell extracts and conditioned media following minoxidil stimulation. These studies strongly support the likely involvement of minoxidil in the development of dermal papilla vascularization via a stimulation of VEGF expression, and support the hypothesis that minoxidil has a physiological role in maintaining a good vascularization of hair follicles in androgenetic alopecia.
Two studies support the hypothesis that minoxidil has a physiological role in maintaining a good vascularization of hair follicles in androgenetic alopecia and VEGF protein production increases in cel
APA 7
Lachgar, S., Charveron, M., Gall, Y., & Bonafe, J. L. (1998). Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells.. The British journal of dermatology, 138(3), 407-11. https://doi.org/10.1046/j.1365-2133.1998.02115.x
Vancouver
Lachgar S, Charveron M, Gall Y, Bonafe JL. Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Brit. jour. derm.. 1998;138(3):407-11. doi:10.1046/j.1365-2133.1998.02115.x
AMA 11
Lachgar S, Charveron M, Gall Y, Bonafe JL. Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Brit. jour. derm.. 1998;138(3):407-11. doi:10.1046/j.1365-2133.1998.02115.x
Chicago
Lachgar, S., Charveron, M., Gall, Y., and Bonafe, J. L.. 1998. "Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells." The British journal of dermatology 138 (3): 407-11. https://doi.org/10.1046/j.1365-2133.1998.02115.x
MLA 9
Lachgar, S., et al. "Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells." The British journal of dermatology, vol. 138, no. 3, 1998, pp. 407-11. doi:10.1046/j.1365-2133.1998.02115.x.
PMID
9580790 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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