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Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche.

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The Journal of pathology 📖 저널 OA 48.1% 2021: 2/3 OA 2022: 1/1 OA 2023: 1/13 OA 2024: 2/15 OA 2025: 28/36 OA 2026: 24/42 OA 2021~2026 2013 Vol.231(2) p. 236-47 피인용 70회 cited 254 RCR 7.26 Hair Growth and Disorders
TL;DR The possibility that LPP represents an autoimmune disease in whose pathogenesis IFNγ‐induced bulge IP collapse plays an important role is raised, as LPP is an excellent model disease for studying and preventing immune destruction of human epithelial stem cells in situ.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-09
📑 코퍼스 인용 관계 · 인용됨 70
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연도별 인용 (2013–2026) · 합계 252
OpenAlex 토픽 · Hair Growth and Disorders Skin and Cellular Biology Research Wnt/β-catenin signaling in development and cancer

Harries MJ, Meyer K, Chaudhry I, E Kloepper J, Poblet E, Griffiths CE

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Abstract

Lichen planopilaris (LPP) is a chronic inflammatory disease of unknown pathogenesis that leads to permanent hair loss. Whilst destruction of epithelial hair follicle stem cells (eHFSCs) that reside in an immunologically protected niche of the HF epithelium, the bulge, is a likely key event in LPP pathogenesis, this remains to be demonstrated. We have tested the hypotheses that bulge immune privilege (IP) collapse and inflammation-induced eHFSC death are key components in the pathogenesis of LPP. Biopsies of lesional and non-lesional scalp skin from adult LPP patients (n = 42) were analysed by quantitative (immuno)histomorphometry, real-time quantitative polymerase chain reaction (qRT-PCR), laser capture microdissection and microarray analysis, or skin organ culture. At both the protein and transcriptional level, lesional LPP HFs showed evidence for bulge IP collapse (ie increased expression of MHC class I and II, β2microglobulin; reduced TGFβ2 and CD200 expression). This was accompanied by a Th1-biased cytotoxic T cell response (ie increased CD8(+) GranzymeB(+) T cells and CD123(+) plasmacytoid dendritic cells, with increased CXCR3 expression) and increased expression of interferon-inducible chemokines (CXCL9/10/11). Interestingly, lesional LPP eHFSCs showed both increased proliferation and apoptosis in situ. Microarray analysis revealed a loss of eHFSC signatures and increased expression of T cell activation/binding markers in active LPP, while bulge PPARγ transcription was unaltered compared to non-lesional LPP HFs. In organ culture of non-lesional LPP skin, interferon-γ (IFNγ) induced bulge IP collapse. LPP is an excellent model disease for studying and preventing immune destruction of human epithelial stem cells in situ. These novel findings raise the possibility that LPP represents an autoimmune disease in whose pathogenesis IFNγ-induced bulge IP collapse plays an important role. Therapeutically, bulge IP protection/restoration may help to better manage this highly treatment-resistant cicatricial alopecia.
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The possibility that LPP represents an autoimmune disease in whose pathogenesis IFNγ‐induced bulge IP collapse plays an important role is raised, as LPP is an excellent model disease for studying and

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↓ .bib ↓ .ris
APA 7 Harries, M. J., Meyer, K., Chaudhry, I., J, E. K., Poblet, E., Griffiths, C. E., & Paus, R. (2013). Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche.. The Journal of pathology, 231(2), 236-47. https://doi.org/10.1002/path.4233
Vancouver Harries MJ, Meyer K, Chaudhry I, J EK, Poblet E, Griffiths CE, et al. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche. The Journal of pathology. 2013;231(2):236-47. doi:10.1002/path.4233
AMA 11 Harries MJ, Meyer K, Chaudhry I, J EK, Poblet E, Griffiths CE, et al. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche. The Journal of pathology. 2013;231(2):236-47. doi:10.1002/path.4233
Chicago Harries, M. J., Meyer, K., Chaudhry, I., J, E. K., Poblet, E., Griffiths, C. E., and Paus, R.. 2013. "Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche." The Journal of pathology 231 (2): 236-47. https://doi.org/10.1002/path.4233
MLA 9 Harries, M. J., et al. "Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche." The Journal of pathology, vol. 231, no. 2, 2013, pp. 236-47. doi:10.1002/path.4233.
PMID 23788005 ↗
DOI 10.1002/path.4233

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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그래프 OA 노드: 8/8 (100%) · 참조 0편 · 후속 8편

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