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90건 · 최신순- Microsurgical outcomes and prognostic analysis of cerebellar gliomas; pathology, molecular biomarkers, and novel clinical insights: a retrospective study.
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Optimal target localization for botulinum toxin A in treating splenius muscles dystonia based on the distribution of intramuscular nerves and spindles.
Botulinum toxin A injection is commonly used to treat splenius muscle dystonia; however, the optimal injection site within the muscle remains unidentified. This study identified the optimal target for botulinum toxin A based on the distribu…
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Spiky Nanoparticle-Gel Composite for Efficient Intravesical Botulinum Toxin A Delivery and Treatment of Overactive Bladder.
Overactive bladder (OAB) is a symptomatic disease that is difficult to treat. This study developed APTES-functionalized spiky titanium dioxide nanoparticles (ASNPs) loaded with botulinum toxin A (ASNP@BA), which is coated with P407/HA (HP) …
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Cryo-EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits.
Botulinum neurotoxin type A (BoNT/A) has been extensively used in treating a wide range of neurological disorders and aesthetics. However, insufficient binding affinity between BoNT/A and its receptor SV2C could lead to mild to severe side …
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Simulation-driven experiments resolve throttle pedal vibration issues.
This study investigates the resolution of accelerator pedal vibration issues during horn activation in vehicle tuning through finite element analysis combined with real-world test data. For certain facelift models experiencing NVH challenge…
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Forehead Overfilling After Autologous Fat Grafting: Literature Review and Retrospective Evaluation of MRI-Guided Microliposuction for Revision.
[BACKGROUND] Forehead overfilling after autologous fat grafting (AFG) can persist as a distressing, conspicuous frontal protrusion, yet its occurrence and dedicated subtractive revision strategies remain underreported. This study aims to re…
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Improvement of Mild Nasal Contour Imperfections With Autologous Fat Grafting in East Asian Females: Techniques and Anatomy.
[BACKGROUND] East Asian women often present with mild nasal contour imperfections for which they are unwilling to undergo open rhinoplasty because the potential risks outweigh the modest severity. Autologous fat grafting is a mature techniq…
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The effect of preoperative oral carbohydrate on the perioperative period of fibula free flap surgery in patients with oral cancer: a retrospective study.
[OBJECTIVE] This study examines the effects of preoperative oral carbohydrates on the perioperative period of Fibula Free Flap surgery in oral cancer patients, aiming to enhance postoperative recovery. [METHODS] The study involved 89 patie…
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Feasibility and Clinical Efficacy of Minimally Invasive Straight-Incision Endodontic Microsurgery Guided by 3-Dimensional Printed Templates: A Retrospective Case Series.
[INTRODUCTION] Endodontic microsurgery (EMS) is a minimally invasive treatment for persistent periapical lesions. This study evaluates the accuracy and outcomes of a straight-incision EMS guided by 3-dimensional (3D)-printed template, with …
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Comparative effectiveness of 24-MHz high-frequency ultrasound versus ICG for preoperative lymphatic mapping in secondary lower limb lymphedema: A retrospective study.
[BACKGROUND] Preoperative lymphatic vessel mapping is essential for lymphaticovenous anastomosis (LVA). This study compared high-frequency ultrasound (HFUS) and indocyanine green (ICG) fluorescent lymphography in preoperative localization f…
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Is Vibration Anesthesia Effective and Safe for Pain Reduction in Botulinum Toxin Injection? A Randomized Split-Face Controlled Trial and Cadaver Experiment.
[BACKGROUND] Pain is an important issue in botulinum toxin injection. Vibration anesthesia is a noninvasive method for pain alleviation, but few studies have reported its use during botulinum toxin injection. [OBJECTIVES] The aim of this s…
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Efficacy of adipose stromal cells-enriched high-density fat graft combined with BTX-A for Raynaud's phenomenon: a prospective cohort study.
[BACKGROUND] Conventional treatments for Raynaud's phenomenon (RP) often show limited effectiveness due to their inability to address both vascular and inflammatory aspects. This study evaluates the combination of high-density fat grafting …
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Efficacy and Safety of Hyaluronic Acid Combined with Botulinum Toxin Type A in the Treatment of Midcheek Groove: A Prospective Study.
[BACKGROUND] The midcheek groove, a diagonal wrinkle in the infraorbital and infrazygomatic regions, disrupts the entire midface smooth lines and impacts facial aesthetics. Despite current treatments' limited effectiveness, including hyalur…
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Efficacy of botulinum toxin and surgery in managing acute acquired comitant esotropia.
[BACKGROUND] Acute acquired comitant esotropia (AACE) can significantly impair binocular vision, and its prevalence is increasing. This study aims to compare the effectiveness of botulinum toxin (BTX) injections with strabismus surgery in p…
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TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion.
[AIMS/HYPOTHESIS] Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying mechanisms regulating glucagon secretion and alpha cell dysfunction remain unclear. While insulin secr…
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Atrophy Masseter Recovery by Electrical Stimulation Mediated M2-Like Macrophage Polarisation via JAK/PI3K/AKT Pathway.
[BACKGROUND] Atrophy of the masseter muscle can result in an aged facial appearance and diminished chewing function. Electrical stimulation (ES) is known for its ability to facilitate tissue healing and functional recovery, but its precise …
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Engineered Exosomes Complexed with Botulinum Toxin Type A for Enhanced Anti-Aging Effects on Skin.
Skin aging is commonly characterized by increased wrinkles, loss of elasticity, and hyperpigmentation, significantly affecting personal appearance and quality of life. Although botulinum toxin type A (BTX-A) has been widely applied in cosme…
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Trends, Hotspots, and Future Directions of Research on Pain in Dystonia: A Bibliometric Analysis.
[INTRODUCTION] Pain in dystonia is closely related neurological disorders, with significant impact on patients' quality of life. This study aims to conduct a bibliometric analysis to examine the development trends, research hotspots, and fu…
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Hypoxic cancer-associated fibroblast exosomal circSTAT3 drives triple negative breast cancer stemness via miR-671-5p/NOTCH1 signaling.
[BACKGROUND] The hypoxic tumor microenvironment, particularly hypoxia-conditioned cancer-associated fibroblasts (CAFs), drives breast cancer (BC) progression and therapy resistance. However, the molecular mechanisms linking hypoxic CAFs to …
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Wide Double-Eyelid Fold Repair Using an Orbital Septum Flap and an Suborbicularis Oculi Fascial-Fat Flap in Cases Requiring Preservation of the Original Incision Scar.
[BACKGROUND] Double-eyelid blepharoplasty is a common cosmetic surgery. However, blepharoplasty can lead to poor results, necessitating repair surgery. One of the most frequent poor results after double-eyelid blepharoplasty is an excessive…
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A New Method of Lower Eyelid Blepharoplasty with Tear Trough Deformity and Mid-face Rejuvenation: Elevating Suborbicularis Oculi Fat and Suturing the Orbital Septum and Orbital Fat as a Whole for Fixation.
[OBJECTIVE] Exploring the clinical effects of the method using elevating the suborbicularis oculi fat (SOOF) and suturing it with the orbital septum and orbital fat as a whole for fixation to correct lower eyelid bags and tear trough deform…
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The Mediating Roles of Objectified Body Consciousness About Acceptance of Cosmetic Surgery Among International Students in China.
[BACKGROUND] Studies on acceptance of cosmetic surgery may not be cross-culturally invariant, but little is known about it in non-Western populations. Therefore, it is necessary to develop cross-cultural research on it. [METHODS] 230 inter…
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Semiphysical Design Concept for Developing Miniaturized Microrobots .
The miniaturization of biomedical microrobots is crucial for their applications. However, it is challenging to reduce their size while maintaining their biomedical functions. To resolve this contradiction, we propose a semiphysical design …
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Endodontic Microsurgery With an Autonomous Robotic System: A Clinical Report.
[INTRODUCTION] Endodontic microsurgery (EMS) requires minimally invasive osteotomy and accurate root-end resection, which can be challenging in many instances. Evidence suggests that autonomous robotic systems can significantly enhance the …
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Enhancing the Extent of Resection in Glioma Surgery Through the Integration of Intraoperative Contrast-Enhanced Ultrasound and Fluorescein Sodium.
[OBJECTIVE] Due to the infiltrative nature and high local recurrence of gliomas, particularly high-grade gliomas, gross total resection (GTR) of a tumor is the first critical step in treatment. This study aimed to determine whether the inte…
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Predictive Factors for Delayed Recovery From Anesthesia in Patients Receiving Free Vascularized Flap Reconstruction for Head and Neck Defects: A Retrospective Cohort Study.
[OBJECTIVE] Free flap reconstruction for head and neck defects is currently a common procedure. This study aimed to create and validate a predictive model for identifying patients at risk of delayed recovery from anesthesia after free flap …
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Application of Free Flaps in Reconstruction of Head and Neck Soft Tissue Defects With Bone Exposure.
[BACKGROUND] Reconstruction of head and neck soft tissue defects with bone exposure is both challenging and technically demanding for plastic surgeon. Objectives in head and neck soft tissue defects with bone exposure reconstruction are con…
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Innovative Clinical Scenario Simulator for Step-by-Step Microsurgical Training.
[BACKGROUND] Microsurgical training should be implemented with consideration of operative difficulties that occur in actual clinical situations. We evaluated the effectiveness of a novel clinical scenario simulator for step-by-step microsu…
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Light-Armed Nitric Oxide-Releasing Micromotor .
The delivery of NO at a high spatiotemporal precision is important but still challenging for existing NO-releasing platforms due to the lack of precise motion control and limited biomedical functions. In this work, we propose an alternative…
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Treatment options for unilateral vestibular schwannoma: a network meta-analysis.
This study aimed to explore the effect of observation, microsurgery, and radiotherapy for patients with vestibular schwannoma (VS). We searched PubMed, Medline, Embase, Web of Science, and Cochrane library from their establishment to July 3…