Alopecia areata: Current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines.
4/5 보강
TL;DR
The latest understanding of the etiopathogenesis and pathophysiology, and update on therapeutic approaches with future perspectives are summarized for AA, following the current version of the JDA AA management guidelines.
📑 코퍼스 인용 관계
· 인용됨 49
📑 인용한 논문 (6) ▾
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연도별 인용 (2022–2026) · 합계 119
OpenAlex 토픽 ·
Hair Growth and Disorders
Dermatology and Skin Diseases
Autoimmune Bullous Skin Diseases
The latest understanding of the etiopathogenesis and pathophysiology, and update on therapeutic approaches with future perspectives are summarized for AA, following the current version of the JDA AA m
APA
Masahiro Fukuyama, Taisuke Ito, Manabu Ohyama (2022). Alopecia areata: Current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines.. The Journal of dermatology, 49(1), 19-36. https://doi.org/10.1111/1346-8138.16207
MLA
Masahiro Fukuyama, et al.. "Alopecia areata: Current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines.." The Journal of dermatology, vol. 49, no. 1, 2022, pp. 19-36.
PMID
34709679 ↗
Abstract 한글 요약
Alopecia areata (AA) is a relatively common nonscarring hairloss disease characterized by an autoimmune response to anagen hair follicles (HFs). Accumulated evidence suggests that collapse of the HF immune privilege subsequent to triggering events, represented by viral infection, leads to autoimmune response in which autoreactive cytotoxic CD8+NKG2D+ T cells mainly target exposed HF autoantigens. AA had been recognized as type 1 inflammatory disease, but recent investigations have suggested some roles of type 2- and Th17-associated mediators in AA pathogenesis. The significance of psychological stress in AA pathogenesis is less emphasized nowadays, but psychological comorbidities, such as depression and anxiety, attract greater interest in AA management. In this regard, the disease severity may not solely be evaluated by the extent of hair loss. Use of trichoscopy markedly improved the resolution of the diagnosis and evaluation of the phase of AA, which is indispensable for the optimization of treatment. For the standardization of AA management, the establishment of guidelines/expert consensus is pivotal. Indeed, the Japanese Dermatological Association (JDA) and other societies and expert groups have published guidelines/expert consensus reports, which mostly recommend intralesional/topical corticosteroid administration and contact immunotherapy as first-line treatments, depending on the age, disease severity, and activity of AA. The uniqueness of the JDA guidelines can be found in their descriptions of intravenous corticosteroid pulse therapy, antihistamines, and other miscellaneous domestically conducted treatments. Considering the relatively high incidence of spontaneous regression in mild AA and its intractability in severe subsets, the importance of course observation is also noted. Evidenced-based medicine for AA is currently limited, however, novel therapeutic approaches, represented by JAK inhibitors, are on their way for clinical application. In this review, the latest understanding of the etiopathogenesis and pathophysiology, and update on therapeutic approaches with future perspectives are summarized for AA, following the current version of the JDA AA management guidelines.
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 합병증 | infection
|
감염 | dict | 1 | |
| 합병증 | infection
|
감염 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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- Alopecia Areata: An Updated Review for 2023.
- Deciphering the Complex Immunopathogenesis of Alopecia Areata.
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- How Our Microbiome Influences the Pathogenesis of Alopecia Areata.
- Trichoscopy pattern in alopecia areata: A systematic review and meta-analysis.
- Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Dis…
- Prevalence, comorbidities, and treatment patterns of Japanese patients with alopecia areata: A descr…
- Alopecia Areata: Pathogenesis, Diagnosis, and Therapies.
- Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review.
- Patient-Reported Burden of Severe Alopecia Areata: First Results from the Multinational Alopecia Are…
- Diagnosis and Management of Alopecia Areata: A Saudi Expert Consensus Statement (2023).
- Exploring the Role of Gut Microbiota in Patients with Alopecia Areata.
- The Role of Minoxidil in Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis.
- Hair regrowth in alopecia areata and re-pigmentation in vitiligo in response to treatment: Commonali…
- Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities.
- Laser and light therapy combined with topical minoxidil for alopecia areata: a systematic review and…
- Hair Follicles as a Critical Model for Monitoring the Circadian Clock.
- Identifying effective immune biomarkers in alopecia areata diagnosis based on machine learning metho…
- Comparative efficacy and safety of systemic steroids, oral JAK inhibitors and Contact Immunotherapy …
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이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
같은 제1저자의 인용 많은 논문 (5)
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- Elucidation of demographic, clinical and trichoscopic features for early diagnosis of self-healing acute diffuse and total alopecia.
- Chronological clinicopathological characterization of rapidly progressive alopecia areata resistant to multiple i.v. corticosteroid pulse therapies: An implication for improving the efficacy.
- Use of trichoscopy for the diagnosis of alopecia areata coexisting with primary scarring alopecia in a female hair loss patient.
- Immunohistochemical dissection of cystic panfolliculoma focusing on the expression of multiple hair follicle lineage markers with an insight into the pathogenesis.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
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Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
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Epidemiology and burden of alopecia areata: a systematic review.
TL;DRAA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approxi…
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Two Phase 3 Trials of Baricitinib for Alopecia Areata.
TL;DRIn two phase 3 trials involving patients with severe alopecia areata, oral baricitinib was superior to placebo with respect to hair regrowth at 36 weeks.
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Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
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Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…