Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth.
4/5 보강
TL;DR
The pivotal role of DPCs in the forefront of hair research as screening platforms is highlighted by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.
📑 코퍼스 인용 관계
· 인용됨 51
📑 인용한 논문 (6) ▾
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연도별 인용 (2018–2026) · 합계 149
OpenAlex 토픽 ·
Hair Growth and Disorders
Dermatologic Treatments and Research
Wound Healing and Treatments
The pivotal role of DPCs in the forefront of hair research as screening platforms is highlighted by providing insights into mechanistic action at cellular level, which may further direct the developme
APA
Alka Madaan, Ritu Verma, et al. (2018). Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth.. International journal of cosmetic science, 40(5), 429-450. https://doi.org/10.1111/ics.12489
MLA
Alka Madaan, et al.. "Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth.." International journal of cosmetic science, vol. 40, no. 5, 2018, pp. 429-450.
PMID
30144361 ↗
Abstract 한글 요약
Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 3 | |
| 해부 | hair follicle
|
모낭 | dict | 3 | |
| 질환 | hirsutism
|
다모증 | dict | 1 | |
| 질환 | hirsutism
|
다모증 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
- The Molecular Mechanism of Natural Products Activating Wnt/β-Catenin Signaling Pathway for Improving…
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- Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?
- Activation of Hair Cell Growth Factors by Linoleic Acid in Seed.
- Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of…
- 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoti…
- Design of In Vitro Hair Follicles for Different Applications in the Treatment of Alopecia-A Review.
- Micro-Current Stimulation Has Potential Effects of Hair Growth-Promotion on Human Hair Follicle-Deri…
- Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules i…
- CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long …
- Application of Non-Pharmacologic Therapy in Hair Loss Treatment and Hair Regrowth.
- Comparison of Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from L. c…
- Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells.
- Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair …
- Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human F…
- Hair growth-promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the W…
- Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during …
- Synergistic Phytochemical and Pharmacological Actions of Hair Rise Microemulsion: A Novel Herbal For…
- Phloroglucinol Enhances Anagen Signaling and Alleviates HO-Induced Oxidative Stress in Human Dermal …
- Bee Venom Stimulates Growth Factor Release from Adipose-Derived Stem Cells to Promote Hair Growth.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
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Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
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Alopecia areata: A multifactorial autoimmune condition.
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Hair follicle immune privilege and its collapse in alopecia areata.
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Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development.
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