The autoimmune basis of alopecia areata: a comprehensive review.
4/5 보강
TL;DR
Recent studies suggest that intervention of the JAK pathway may have a potential therapeutic efficacy for AA, and multiple treatment options including the use of broad acting corticosteroids appear to be relatively effective in mild cases.
📑 코퍼스 인용 관계
· 인용됨 83
📑 인용한 논문 (6) ▾
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연도별 인용 (2015–2026) · 합계 255
OpenAlex 토픽 ·
Hair Growth and Disorders
RNA regulation and disease
Autoimmune Bullous Skin Diseases
Abstract 🌐 Abstract
Alopecia areata (AA) is a common, non-scarring dermatologic condition regularly distinguished by patches of hair loss on the scalp also manifesting in other, severe forms, including alopecia totalis (total loss of hair on the scalp) and alopecia universalis (complete loss of hair on the scalp and body). AA is a clinically heterogeneous disease with greatly varying yet typical symptoms, but the etiology for AA remains an enigma. However, clinical and experimental studies have pointed to autoimmune involvement, specifically regarding immune privilege sites of the hair follicles and the infiltration of CD4+ and CD8+ T cells and a predominant Th1 cytokine profile. Environmental insults, such as viral infections, trauma and genetic predisposition are also believed to contribute to the disease process. Multiple treatment options including the use of broad acting corticosteroids appear to be relatively effective in mild cases, however the clinical management of more severe forms of AA is much more difficult. Recent studies suggest that intervention of the JAK pathway may have a potential therapeutic efficacy for AA.
Recent studies suggest that intervention of the JAK pathway may have a potential therapeutic efficacy for AA, and multiple treatment options including the use of broad acting corticosteroids appear to
APA 7
Islam, N., Leung, P. S., Huntley, A. C., & Gershwin, M. E. (2015). The autoimmune basis of alopecia areata: A comprehensive review.. Autoimmunity reviews, 14(2), 81-9. https://doi.org/10.1016/j.autrev.2014.10.014
Vancouver
Islam N, Leung PS, Huntley AC, Gershwin ME. The autoimmune basis of alopecia areata: a comprehensive review. Autoimmunity reviews. 2015;14(2):81-9. doi:10.1016/j.autrev.2014.10.014
AMA 11
Islam N, Leung PS, Huntley AC, Gershwin ME. The autoimmune basis of alopecia areata: a comprehensive review. Autoimmunity reviews. 2015;14(2):81-9. doi:10.1016/j.autrev.2014.10.014
Chicago
Islam, N., Leung, P. S., Huntley, A. C., and Gershwin, M. E.. 2015. "The autoimmune basis of alopecia areata: a comprehensive review." Autoimmunity reviews 14 (2): 81-9. https://doi.org/10.1016/j.autrev.2014.10.014
MLA 9
Islam, N., et al. "The autoimmune basis of alopecia areata: a comprehensive review." Autoimmunity reviews, vol. 14, no. 2, 2015, pp. 81-9. doi:10.1016/j.autrev.2014.10.014.
PMID
25315746 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | scalp
|
두피 | dict | 3 | |
| 해부 | scalp
|
두피 | dict | 3 | |
| 해부 | scalp
|
두피 | dict | 3 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
- Epidemiology and burden of alopecia areata: a systematic review.
- "'You lose your hair, what's the big deal?' I was so embarrassed, I was so self-conscious, I was so …
- The Role of Micronutrients in Alopecia Areata: A Review.
- Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strate…
- Complementary and Alternative Treatments for Alopecia: A Comprehensive Review.
- Alopecia Areata Treatment Patterns, Healthcare Resource Utilization, and Comorbidities in the US Pop…
- Drug discovery for alopecia: gone today, hair tomorrow.
- The Invisible Impact of a Visible Disease: Psychosocial Impact of Alopecia Areata.
- Utilization of Mental Health Resources and Complementary and Alternative Therapies for Alopecia Area…
- Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with A…
- Understanding autoimmunity of vitiligo and alopecia areata.
- Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatm…
- Development of the Scalp Hair Assessment PRO™ measure for alopecia areata.
- Serum Vitamin D in patients with alopecia areata.
- Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory…
- Cumulative Life Course Impairment of Alopecia Areata.
- Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82.
- Treatments for alopecia areata: a network meta-analysis.
- Patient characteristics and disease burden of alopecia areata in the Danish Skin Cohort.
- Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from p…
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
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Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
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Epidemiology and burden of alopecia areata: a systematic review.
TL;DRAA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approxi…
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Two Phase 3 Trials of Baricitinib for Alopecia Areata.
TL;DRIn two phase 3 trials involving patients with severe alopecia areata, oral baricitinib was superior to placebo with respect to hair regrowth at 36 weeks.
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Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
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Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…