Regulation of hair follicle development by exosomes derived from dermal papilla cells.
4/5 보강
TL;DR
DPC-Exos contribute to the regulation of HF growth and development, and provide a potential avenue for the treatment of hair loss.
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연도별 인용 (2017–2026) · 합계 150
OpenAlex 토픽 ·
Hair Growth and Disorders
Mesenchymal stem cell research
Skin and Cellular Biology Research
DPC-Exos contribute to the regulation of HF growth and development, and provide a potential avenue for the treatment of hair loss.
APA
Lijuan Zhou, Han Wang, et al. (2018). Regulation of hair follicle development by exosomes derived from dermal papilla cells.. Biochemical and biophysical research communications, 500(2), 325-332. https://doi.org/10.1016/j.bbrc.2018.04.067
MLA
Lijuan Zhou, et al.. "Regulation of hair follicle development by exosomes derived from dermal papilla cells.." Biochemical and biophysical research communications, vol. 500, no. 2, 2018, pp. 325-332.
PMID
29654758 ↗
Abstract 한글 요약
[BACKGROUND] Dermal papilla cells (DPCs) play a critical role in the regulation of hair follicle (HF) growth, formation, and cycling. DPCs are thought to regulate HF growth through a paracrine mechanism, in which exosomes may play a critical role.
[METHODS] DPC-Exos were cutaneously injected into HFs at different HF cycle stages and the effects were evaluated by histological and immunohistochemical analyses. The effects of DPC-Exos on proliferation, migration, and cell cycle status of outer root sheath cells (ORSCs) were evaluated. After treatment of DPC-Exos, changes in mRNA and protein levels of β-catenin and Sonic hedgehog (Shh) in ORSCs were detected.
[RESULTS] DPC-Exos were approximately 105 nm in diameter and expressed tumor susceptibility gene 101, cluster of differentiation (CD)9, and CD63. Injection of DPC-Exos accelerated the onset of HF anagen and delayed catagen in mice. Immunohistochemical analyses revealed that β-catenin and Shh levels were upregulated in the skin. In vitro, DPC-Exo treatment enhanced ORSC proliferation and migration, and stimulated the expression of β-catenin and Shh.
[CONCLUSION] DPC-Exos contribute to the regulation of HF growth and development, and provide a potential avenue for the treatment of hair loss.
[METHODS] DPC-Exos were cutaneously injected into HFs at different HF cycle stages and the effects were evaluated by histological and immunohistochemical analyses. The effects of DPC-Exos on proliferation, migration, and cell cycle status of outer root sheath cells (ORSCs) were evaluated. After treatment of DPC-Exos, changes in mRNA and protein levels of β-catenin and Sonic hedgehog (Shh) in ORSCs were detected.
[RESULTS] DPC-Exos were approximately 105 nm in diameter and expressed tumor susceptibility gene 101, cluster of differentiation (CD)9, and CD63. Injection of DPC-Exos accelerated the onset of HF anagen and delayed catagen in mice. Immunohistochemical analyses revealed that β-catenin and Shh levels were upregulated in the skin. In vitro, DPC-Exo treatment enhanced ORSC proliferation and migration, and stimulated the expression of β-catenin and Shh.
[CONCLUSION] DPC-Exos contribute to the regulation of HF growth and development, and provide a potential avenue for the treatment of hair loss.
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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