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The cell biology of human hair follicle pigmentation.

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4/5 보강
Pigment cell & melanoma research 📖 저널 OA 42.6% 2021: 0/2 OA 2022: 0/1 OA 2023: 2/7 OA 2024: 2/7 OA 2025: 7/13 OA 2026: 6/9 OA 2021~2026 2011 Vol.24(1) p. 75-88 피인용 15회 cited 149 RCR 4.14 melanin and skin pigmentation
TL;DR The status of the human hair follicle melanocyte is raised and some species‐specific issues involved are highlighted which the general reader of the pigmentation literature (with its substantial mouse‐based data) may not fully appreciate.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-09
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연도별 인용 (2012–2026) · 합계 143
OpenAlex 토픽 · melanin and skin pigmentation Skin Protection and Aging Hair Growth and Disorders

Tobin DJ

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The status of the human hair follicle melanocyte is raised and some species‐specific issues involved are highlighted which the general reader of the pigmentation literature (with its substantial mouse

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↓ .bib ↓ .ris
APA Desmond J. Tobin (2011). The cell biology of human hair follicle pigmentation.. Pigment cell & melanoma research, 24(1), 75-88. https://doi.org/10.1111/j.1755-148X.2010.00803.x
MLA Desmond J. Tobin. "The cell biology of human hair follicle pigmentation.." Pigment cell & melanoma research, vol. 24, no. 1, 2011, pp. 75-88.
PMID 21070612 ↗
DOI 10.1111/j.1755-148X.2010.00803.x

Abstract

Although we have made significant progress in understanding the regulation of the UVR-exposed epidermal-melanin unit, we know relatively little about how human hair follicle pigmentation is regulated. Progress has been hampered by gaps in our knowledge of the hair growth cycle's controls, to which hair pigmentation appears tightly coupled. However, pigment cell researchers may have overly focused on the follicular melanocytes of the nocturnal and UVR-shy mouse as a proxy for human epidermal melanocytes. Here, I emphasize the epidermis-follicular melanocyte pluralism of human skin, as research models for vitiligo, alopecia areata and melanoma, personal care/cosmetics innovation. Further motivation could be in finding answers to why hair follicle and epidermal pigmentary units remain broadly distinct? Why melanomas tend to originate from epidermal rather than follicular melanocytes? Why multiple follicular melanocyte sub-populations exist? Why follicular melanocytes are more sensitive to aging influences? In this perspective, I attempt to raise the status of the human hair follicle melanocyte and highlight some species-specific issues involved which the general reader of the pigmentation literature (with its substantial mouse-based data) may not fully appreciate.

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