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Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction.

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4/5 보강
Tissue engineering 2007 Vol.13(5) p. 975-82 피인용 42회 cited 170 RCR 3.77 Hair Growth and Disorders
TL;DR It is suggested that FGF-2 is essential for dermal papilla cell culture and that sphere formation partially models the intact DP, resulting in hair follicle induction, even by later passaged cells.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-10
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OpenAlex 토픽 · Hair Growth and Disorders Skin and Cellular Biology Research Wnt/β-catenin signaling in development and cancer

Osada A, Iwabuchi T, Kishimoto J, Hamazaki TS, Okochi H

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Abstract

We have succeeded in culturing dermal papilla (DP) cells long term and developed new techniques that enhance their hair follicle-inducing efficiency in a patch assay. The outgrowing DP cells from mouse vibrissae were markedly stimulated by 10% fetal bovine serum-Dulbecco's modified essential medium that included fibroblast growth factor-2 (FGF-2). Moreover, the potency of proliferation was maintained during serial cultivations (more than 30 passages). We combined these established DP cells with epidermal cells and implanted them subcutaneously into athymic mice to examine their hair follicle-inducing ability. New hair follicles were induced by dissociated DP cells at earlier passages (under passage 4), but the cells from later passages could not induce follicles. We next aggregated the DP cells to form spheres and then injected them with epidermal cells. Unlike the dissociated DP cells, the spheres made from the later passaged cells (more than 10 passages) did induce new hair follicles. We examined several genes specific for DP of anagen follicles and confirmed that their expression level was elevated in the spheres compared with their expression level in adherent DP cells. These results suggest that FGF-2 is essential for dermal papilla cell culture and that sphere formation partially models the intact DP, resulting in hair follicle induction, even by later passaged cells.
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It is suggested that FGF-2 is essential for dermal papilla cell culture and that sphere formation partially models the intact DP, resulting in hair follicle induction, even by later passaged cells.

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↓ .bib ↓ .ris
APA 7 Osada, A., Iwabuchi, T., Kishimoto, J., Hamazaki, T. S., & Okochi, H. (2007). Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction.. Tissue engineering, 13(5), 975-82. https://doi.org/10.1089/ten.2006.0304
Vancouver Osada A, Iwabuchi T, Kishimoto J, Hamazaki TS, Okochi H. Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction. Tissue engineering. 2007;13(5):975-82. doi:10.1089/ten.2006.0304
AMA 11 Osada A, Iwabuchi T, Kishimoto J, Hamazaki TS, Okochi H. Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction. Tissue engineering. 2007;13(5):975-82. doi:10.1089/ten.2006.0304
Chicago Osada, A., Iwabuchi, T., Kishimoto, J., Hamazaki, T. S., and Okochi, H.. 2007. "Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction." Tissue engineering 13 (5): 975-82. https://doi.org/10.1089/ten.2006.0304
MLA 9 Osada, A., et al. "Long-term culture of mouse vibrissal dermal papilla cells and de novo hair follicle induction." Tissue engineering, vol. 13, no. 5, 2007, pp. 975-82. doi:10.1089/ten.2006.0304.
PMID 17341162 ↗
DOI 10.1089/ten.2006.0304

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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그래프 OA 노드: 8/8 (100%) · 참조 0편 · 후속 8편

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