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Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles.

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The Journal of investigative dermatology 📖 저널 OA 67.5% 2021: 20/22 OA 2022: 11/14 OA 2023: 14/29 OA 2024: 15/36 OA 2025: 35/70 OA 2026: 32/69 OA 2021~2026 2002 Vol.118(1) p. 3-10 피인용 12회 cited 151 OA RCR 2.25 Hair Growth and Disorders
TL;DR D dorsal skin of murine embryos with constitutive deletion of the BMP2/4 antagonist noggin, after transplantation into SCID mice, is characterized by the lack of induction of secondary hair follicles, and by the arrest of primary hair follicle development prior to hair shaft formation.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-10
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연도별 인용 (2012–2025) · 합계 62
OpenAlex 토픽 · Hair Growth and Disorders Skin and Cellular Biology Research Wnt/β-catenin signaling in development and cancer

Botchkarev VA, Botchkareva NV, Sharov AA, Funa K, Huber O, Gilchrest BA

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D dorsal skin of murine embryos with constitutive deletion of the BMP2/4 antagonist noggin, after transplantation into SCID mice, is characterized by the lack of induction of secondary hair follicles,

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APA Vladimir A. Botchkarev, Natalia V. Botchkareva, et al. (2002). Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles.. The Journal of investigative dermatology, 118(1), 3-10. https://doi.org/10.1046/j.1523-1747.2002.01645.x
MLA Vladimir A. Botchkarev, et al.. "Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles.." The Journal of investigative dermatology, vol. 118, no. 1, 2002, pp. 3-10.
PMID 11851869 ↗
DOI 10.1046/j.1523-1747.2002.01645.x

Abstract

Increasing evidence suggests that morphogenesis of the distinct developmental structures derived from the same organ-committed epithelium is controlled by differential mechanisms. As was recently shown in mice with mutations in the downless (dL) gene, induction of primary or tylotrich hair follicles is strikingly dependent of signaling through the Tnf receptor homologue, Edar. Here, we show that dorsal skin of murine embryos with constitutive deletion of the BMP2/4 antagonist noggin, after transplantation into SCID mice, is characterized by the lack of induction of secondary hair follicles, and by the arrest of primary hair follicle development prior to hair shaft formation. The loss of noggin activity was associated with failure to express genes that specify hair follicle cell fates in the epidermis (Lef-1, beta-catenin, Shh) and dermal papilla (p75 kDa neurotrophin receptor, alkaline phosphatase). This suggests that regulation of BMP2/4 signaling by noggin is essential for the induction of secondary hair follicles, as well as for advanced stages of development in primary hair follicles.

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그래프 OA 노드: 8/8 (100%) · 참조 0편 · 후속 8편

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