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Location of stem cells of human hair follicles by clonal analysis.

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Cell 📖 저널 OA 71.5% 2021: 8/10 OA 2022: 6/8 OA 2023: 9/10 OA 2024: 16/19 OA 2025: 56/78 OA 2026: 43/69 OA 2021~2026 1994 Vol.76(6) p. 1063-73 피인용 14회 cited 534 RCR 9.69 Hair Growth and Disorders
TL;DR The hair follicle, like the epidermis, contains keratinocytes with the expected property of stem cells: an extensive proliferative capacity permitting the generation of a large amount of epithelium.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-10
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연도별 인용 (2012–2026) · 합계 146
OpenAlex 토픽 · Hair Growth and Disorders Skin and Cellular Biology Research Wound Healing and Treatments

Rochat A, Kobayashi K, Barrandon Y

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Abstract

We have examined the growth capacity of keratinocytes isolated from human scalp hair follicles. Like the keratinocytes of glabrous epidermis, most of the colony-forming cells are classified as holoclones or meroclones when analyzed in a clonal assay. Some of them have extensive growth potential, as they are able to undergo at least 130 doublings. Therefore, the hair follicle, like the epidermis, contains keratinocytes with the expected property of stem cells: an extensive proliferative capacity permitting the generation of a large amount of epithelium. We have also examined the distribution of clonogenic keratinocytes within the hair follicle. Several hundred colony-forming cells are concentrated at a region below the midpoint of the follicle and outside the hair bulb. This region lies deeper than the site of insertion of the arrector pili muscle, which corresponds with the position of the bulge when the latter can be identified. In contrast, few colony-forming cells are present in the hair bulb, where most of the mitotic activity is observed during the active growth phase of the follicle. Paraclones, which are present both in the midregion and in the bulb of hair follicles, are unlikely to be the transient amplifying cells expected from kinetic studies.
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The hair follicle, like the epidermis, contains keratinocytes with the expected property of stem cells: an extensive proliferative capacity permitting the generation of a large amount of epithelium.

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↓ .bib ↓ .ris
APA 7 Rochat, A., Kobayashi, K., & Barrandon, Y. (1994). Location of stem cells of human hair follicles by clonal analysis.. Cell, 76(6), 1063-73. https://doi.org/10.1016/0092-8674(94)90383-2
Vancouver Rochat A, Kobayashi K, Barrandon Y. Location of stem cells of human hair follicles by clonal analysis. Cell. 1994;76(6):1063-73. doi:10.1016/0092-8674(94)90383-2
AMA 11 Rochat A, Kobayashi K, Barrandon Y. Location of stem cells of human hair follicles by clonal analysis. Cell. 1994;76(6):1063-73. doi:10.1016/0092-8674(94)90383-2
Chicago Rochat, A., Kobayashi, K., and Barrandon, Y.. 1994. "Location of stem cells of human hair follicles by clonal analysis." Cell 76 (6): 1063-73. https://doi.org/10.1016/0092-8674(94)90383-2
MLA 9 Rochat, A., et al. "Location of stem cells of human hair follicles by clonal analysis." Cell, vol. 76, no. 6, 1994, pp. 1063-73. doi:10.1016/0092-8674(94)90383-2.
PMID 8137423 ↗
DOI 10.1016/0092-8674(94)90383-2

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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그래프 OA 노드: 8/8 (100%) · 참조 0편 · 후속 8편

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