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Multiplex CD30/Carbonic Anhydrase IX Lateral Flow Assay for Rapid Triage of Suspected BIA-ALCL in Peri-implant Seroma Fluid.
[BACKGROUND] Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare lymphoma associated with textured implants. Earlier detection and timely implant/capsulectomy reduce morbidity and improve outcomes. CD30 is a sensit…
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A New Clinical Classification Method for Gynecomastia Based on Chest Appearance and MR/CT Images.
[BACKGROUND] Classification theories for gynecomastia often conflate breast ptosis degree with subcutaneous soft tissue composition, leading to further confusion in determining appropriate surgical regions and techniques. To address this, w…
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Lateral Flow Assay to Detect Carbonic Anhydrase IX in Seromas of Breast Implant-Associated Anaplastic Large Cell Lymphoma.
[BACKGROUND/OBJECTIVE] Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has affected more than 1700 women with textured breast implants. About 80% of patients present with fluid (seroma) around their implant. BIA-ALCL can…
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Multiplex Lateral Flow Assay Combining CD30 and IL-10 for the Detection of BIA-ALCL.
[BACKGROUND] Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has affected more than 1700 women. Treatment morbidity is reduced and survival improved by early detection and removal of implant and capsule. [OBJECTIVE] To …
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How Should We Use Hyaluronidase for Dissolving Hyaluronic Acid Fillers?
[BACKGROUND] Hyaluronic acid (HA) fillers are commonly used in esthetic medicine for facial contouring and rejuvenation. However, complications such as overcorrection, vascular occlusion, and irregular filler distribution necessitate the us…
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Sonoanatomy of the Nasal Ala for Botulinum Neurotoxin Injection.
[BACKGROUND] The nasal ala region significantly affects facial aesthetics and function. Botulinum toxin injections may enhance nasal appearance, but their precise impact on underlying muscles remains unexplored. Understanding the muscular a…
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Anatomical etiology of bunny lines based on cadaveric dissection and ultrasonographic evaluation.
Bunny lines are vertical and diagonal wrinkles attributed to contractions of the nasalis muscle. Common management involves botulinum toxin (BoNT) injections into wrinkles immediately below the nasal bridge. Here, we investigated the anatom…
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Optimal Strategies for Autologous Fat Grafting in Breast Augmentation and Reconstruction: A Systematic Review and Network Meta-Analysis.
[BACKGROUND] Cell-assisted lipotransfer (CAL) and platelet-rich plasma (PRP)-assisted lipotransfer have been used to overcome the low survival rate of conventional lipotransfer. However, there is still insufficient evidence to determine whi…
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Single-cell RNA sequencing reveals prolonged polyacrylamide hydrogel stimulation in vivo leads to an immunosuppressive microenvironment and potential tumorigenesis.
[BACKGROUND] Polyacrylamide hydrogel (PAAG) was once a prevalent filler for augmentation surgery. It was banned in China in 2006 due to persistent adverse reactions. However, numerous patients who received PAAG injection still suffer from P…
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IL-9 Is a Biomarker of BIA-ALCL Detected Rapidly by Lateral Flow Assay.
[BACKGROUND] A delayed seroma around breast implants is the most common clinical presentation of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). Interleukin-9 (IL-9), IL-10, and IL-13 concentrations are significantly hi…
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Preventing Bacterial Contamination of Breast Implants Using Infection Mitigation Techniques: An In Vitro Study.
[BACKGROUND] Bacterial contamination of implants has been linked to biofilm formation and subsequent infection, capsular contracture, and breast implant-associated anaplastic large cell lymphoma. Reducing contamination during implant insert…
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The Low-Abundance Plasma Proteome Reveals Differentially Abundant Proteins Associated with Breast Implant Capsular Contracture: A Pilot Study.
Capsular contracture (CC) is one of the most common postoperative complications associated with breast implant-associated infections. The mechanisms that lead to CC remain poorly understood. Plasma is an ideal biospecimen for early proteomi…
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Do repetitive botulinum neurotoxin injections induce muscle fibrosis? Sonographic observation of the masseter muscle.
[OBJECTIVE] In the esthetic field, the masseter muscle is commonly targeted by botulinum neurotoxin for facial contouring. However, multiple botulinum neurotoxin injections have been reported to cause muscle fibrosis. Ultrasonography can be…
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Ultrasonographic Study of the Submandibular Gland for Botulinum Neurotoxin Injection.
[BACKGROUND] Hypertrophied submandibular glands provide a bulky contour to the lower face. Botulinum neurotoxin injection methods are commonly used for facial contouring; however, no studies have suggested injection points because of the la…
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Does injecting small amounts of fillers prevent the development of secondary blindness?
[INTRODUCTION] Inadvertent entry of filler products into the supratrochlear, supraorbital, or dorsal nasal arteries, among other branches of the ophthalmic artery, might result in an immediate and devastating loss of vision. We wanted to ex…
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Adverse Effects Associated with Dermal Filler Treatments: Part II Vascular Complication.
Vascular complications arising from dermal filler treatments pose significant risks, including ischemia, tissue necrosis, and severe outcomes like blindness and pulmonary embolism. This study investigates the mechanisms of vascular complica…
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Review of the Adverse Effects Associated with Dermal Filler Treatments: Part I Nodules, Granuloma, and Migration.
The increase in the use of filler treatments within minimally invasive cosmetic surgery has correspondingly escalated the variety and frequency of associated side effects. Initially, unregulated procedures led to primary side effects such a…
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Self-crossing hyaluronic acid filler with combination use of polydioxanone thread in minipig model.
[INTRODUCTION] The advances of self-crossing hyaluronic acid (SC-HA) fillers combination use with polydioxanone thread in minipigs were examined for compatibility, effectiveness, and immune response. [MATERIALS AND METHODS] A 12-week exper…
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Anatomical Considerations for the Injection of Botulinum Neurotoxin in Shoulder and Arm Contouring.
The utilization of botulinum neurotoxin in the field of body contouring is on the rise. Body contouring procedures typically focus on specific muscle groups such as the superior trapezius, deltoid, and lateral head of the triceps brachii. T…
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A novel approach to treating post-stroke depression: administration of Botulinum Toxin A via local facial injection.
[BACKGROUND] Post-stroke depression (PSD) is a frequent complication following a stroke, characterized by prolonged feelings of sadness and loss of interest, which can significantly impede stroke rehabilitation, increase disability, and rai…
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Oxygen vacancy-engineered cerium oxide mediated by copper-platinum exhibit enhanced SOD/CAT-mimicking activities to regulate the microenvironment for osteoarthritis therapy.
Cerium oxide (CeO) nanospheres have limited enzymatic activity that hinders further application in catalytic therapy, but they have an "oxidation switch" to enhance their catalytic activity by increasing oxygen vacancies. In this study, acc…
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Anatomical Guidelines and Technical Tips for Neck Aesthetics with Botulinum Toxin.
Botulinum toxin can be used for various purposes to enhance neck aesthetics, addressing concerns such as platysmal bands, optimizing the cervicomental angle, preventing worsening of horizontal neckline and decolletage lines during aging, su…
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CD30 Lateral Flow and Enzyme-Linked Immunosorbent Assays for Detection of BIA-ALCL: A Pilot Study.
[INTRODUCTION] Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) commonly presents as a peri-implant effusion (seroma). CD30 (TNFRSF8) is a consistent marker of tumor cells but also can be expressed by activated lymphocyte…
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Diagnosis of breast implant associated anaplastic large cell lymphoma by analysis of cytokines in peri-implant seromas.
More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Ou…
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Improving visualization of free fibula flap perforators and reducing radiation dose in dual-energy CT angiography.
[BACKGROUND] The precise assessment of the perforators of the fibula free flap (FFF) is crucial for minimizing procedure-related complications when harvesting the FFF in patients with maxillofacial lesions. This study aims to investigate th…
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Nitroglycerin improves the visibility of fibula-free flap perforators on computed tomography angiography in patients with oral or maxillofacial lesion.
[PURPOSE] To investigate the improvement of image quality and visualization of fibula-free flap (FFF) perforators on computed tomography angiography (CTA) after administration of sublingual nitroglycerin (NTG) tablets. [METHODS] A total of…
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Anatomical proposal for hyaluronic acid filler injection in subzygomatic arch depression: A dual-plane injection technique.
A subzygomatic arch depression creates a bulky face outline. To smoothen these depressions and correct facial contours, hyaluronic acid filler injection methods are frequently used. However, the complexity of the subzygomatic region make it…
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Anatomical proposal of local anesthesia injection for median nerve block in treating hyperhidrosis with botulinum neurotoxin.
[INTRODUCTION] Hyperhidrosis, causing excessive sweat, can be treated with Botulinum neurotoxin injection. Botulinum toxin, an effective and safe treatment for hyperhidrosis, unfortunately involves significant pain due to multiple injection…
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[Transconjunctival lower eyelid blepharoplasty with "super released" orbital fat in correction of tear trough and palpebromalar groove depression].
[OBJECTIVE] To investigate effectiveness of transconjunctival lower eyelid blepharoplasty with "super released" orbital fat in correction of lower eyelid pouch protrusion and tear trough and palpebromalar groove depression. [METHODS] A cli…
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Sutures positioning technique enhances the predictability and concordance between preoperative simulation and actual outcomes in rhinoplasty.
[BACKGROUND] The predictability and concordance between simulated and actual outcomes in rhinoplasty are uncertain. Here, we introduce a suture positioning technique (SPT), a simple and low-cost method to minimize the gap between the simula…