Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia.
5/5 보강
TL;DR
This study describes androgen receptor (AR) in C57BL/6 mouse hair follicles that can be activated by dihydrotestosterone (DHT) and translocate to the nucleus and designs a mouse model of androgen-induced AGA in vivo and in vitro.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2021–2026) · 합계 167
OpenAlex 토픽 ·
Hair Growth and Disorders
Dermatologic Treatments and Research
melanin and skin pigmentation
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
안드로겐성 탈모(androgenetic alopecia, AGA)의 발병 기전 규명 및 신약 평가에 활용 가능한 동물 모델을 확립하기 위해, C57BL/6 마우스 모낭에서 디하이드로테스토스테론(DHT)이 안드로겐 수용체(androgen receptor, AR)를 활성화시켜 탈모를 유발하는지 검증하고자 함.
【방법】
수컷 C57BL/6 마우스에 DHT를 투여하여 in vivo 모델을 구축하고, 모낭 기관 배양(organ culture)을 통한 ex vivo 모델을 병행 평가함. AR 길항제인 비칼루타마이드(bicalutamide)의 회복 효과를 확인하였으며, 조직학적 분석과 단백질 발현 분석으로 기전을 규명함.
【주요 결과】
DHT는 마우스 모낭의 AR을 활성화시켜 핵 내로 전위시키고, 조기 모발 퇴행·모발 소형화(miniaturization)·모발 밀도 감소·모발 형태 변화를 유발하였음. 이러한 변화는 비칼루타마이드 투여로 부분적으로 회복되어 AR 매개 기전임이 확인됨.
【임상적 시사점 (성형외과 의사 관점)】
본 모델은 AGA 환자에게 시행하는 모발이식(hair transplant) 보조 약물 및 신규 치료제(국소 AR 길항제, 메조테라피 후보 물질 등)의 전임상 효능 평가에 직접 활용 가능함. 특히 비칼루타마이드 같은 AR 길항제의 국소 적용 가능성을 시사하여, 피나스테리드/두타스테리드의 전신 부작용을 우려하는 환자군에서 대안적 치료 전략 개발의 근거가 될 수 있음.
Androgenic alopecia (AGA), also known as male pattern baldness, is one of the most common hair loss diseases worldwide. The main treatments of AGA include hair transplant surgery, oral medicines, and LDL laser irradiation, although no treatment to date can fully cure this disease. Animal models play important roles in the exploration of potential mechanisms of disease development and in assessing novel treatments. The present study describes androgen receptor (AR) in C57BL/6 mouse hair follicles that can be activated by dihydrotestosterone (DHT) and translocate to the nucleus. This led to the design of a mouse model of androgen-induced AGA in vivo and in vitro. DHT was found to induce early hair regression, hair miniaturization, hair density loss, and changes in hair morphology in male C57BL/6 mice. These effects of DHT could be partly reversed by the AR antagonist bicalutamide. DHT had similar effects in an ex vivo model of hair loss. Evaluation of histology, organ culture, and protein expression could explain the mechanism by which DHT delayed hair regrowth.
【연구 목적】 안드로겐성 탈모(androgenetic alopecia, AGA)의 발병 기전 규명 및 신약 평가에 활용 가능한 동물 모델을 확립하기 위해, C57BL/6 마우스 모낭에서 디하이드로테스토스테론(DHT)이 안드로겐 수용체(androgen receptor, AR)를 활성화시켜 탈모를 유발하는지 검증하고자 함.
APA 7
Fu, D., Huang, J., Li, K., Chen, Y., He, Y., Sun, Y., Guo, Y., Du, L., Qu, Q., Miao, Y., & Hu, Z. (2021). Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in c57bl6 mice simulates androgenetic alopecia.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 137, 111247. https://doi.org/10.1016/j.biopha.2021.111247
Vancouver
Fu D, Huang J, Li K, Chen Y, He Y, Sun Y, et al. Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia. Biom. & phar. = Biom. & phar.. 2021;137:111247. doi:10.1016/j.biopha.2021.111247
AMA 11
Fu D, Huang J, Li K, Chen Y, He Y, Sun Y, et al. Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia. Biom. & phar. = Biom. & phar.. 2021;137:111247. doi:10.1016/j.biopha.2021.111247
Chicago
Fu, D., Huang, J., Li, K., Chen, Y., He, Y., Sun, Y., Guo, Y., Du, L., Qu, Q., Miao, Y., and .... 2021. "Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 137: 111247. https://doi.org/10.1016/j.biopha.2021.111247
MLA 9
Fu, D., et al. "Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 137, 2021, pp. 111247. doi:10.1016/j.biopha.2021.111247.
PMID
33517191 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | hair transplant
|
모발이식 | dict | 1 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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