A Subset of TREM2 Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth.
4/5 보강
TL;DR
It is shown that Oncostatin M (OSM), an IL-6 family cytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain HFSC quiescence.
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· 인용됨 36
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연도별 인용 (2019–2026) · 합계 176
OpenAlex 토픽 ·
Hair Growth and Disorders
melanin and skin pigmentation
Dermatology and Skin Diseases
Abstract 🌐 Abstract
Hair growth can be induced from resting mouse hair follicles by topical application of JAK inhibitors, suggesting that JAK-STAT signaling is required for maintaining hair follicle stem cells (HFSCs) in a quiescent state. Here, we show that Oncostatin M (OSM), an IL-6 family cytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain HFSC quiescence. Genetic deletion of the OSM receptor or STAT5 can induce premature HFSC activation, suggesting that the resting telogen stage is actively maintained by the hair follicle niche. Single-cell RNA sequencing revealed that the OSM source is not intrinsic to the hair follicle itself and is instead a subset of TREM2 macrophages that is enriched within the resting follicle and deceases immediately prior to HFSC activation. In vivo inhibition of macrophage function was sufficient to induce HFSC proliferation and hair cycle induction. Together these results clarify how JAK-STAT signaling actively inhibits hair growth.
It is shown that Oncostatin M (OSM), an IL-6 family cytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain HFSC quiescence.
APA 7
Wang, E. C. E., Dai, Z., Ferrante, A. W., Drake, C. G., & Christiano, A. M. (2019). A subset of trem2 dermal macrophages secretes oncostatin m to maintain hair follicle stem cell quiescence and inhibit hair growth.. Cell stem cell, 24(4), 654-669.e6. https://doi.org/10.1016/j.stem.2019.01.011
Vancouver
Wang ECE, Dai Z, Ferrante AW, Drake CG, Christiano AM. A Subset of TREM2 Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell stem cell. 2019;24(4):654-669.e6. doi:10.1016/j.stem.2019.01.011
AMA 11
Wang ECE, Dai Z, Ferrante AW, Drake CG, Christiano AM. A Subset of TREM2 Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell stem cell. 2019;24(4):654-669.e6. doi:10.1016/j.stem.2019.01.011
Chicago
Wang, E. C. E., Dai, Z., Ferrante, A. W., Drake, C. G., and Christiano, A. M.. 2019. "A Subset of TREM2 Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth." Cell stem cell 24 (4): 654-669.e6. https://doi.org/10.1016/j.stem.2019.01.011
MLA 9
Wang, E. C. E., et al. "A Subset of TREM2 Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth." Cell stem cell, vol. 24, no. 4, 2019, pp. 654-669.e6. doi:10.1016/j.stem.2019.01.011.
PMID
30930146 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 4 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- Cell Cycle
- Cell Proliferation
- Dermis
- Female
- Hair
- Hair Follicle
- Humans
- Janus Kinase 2
- Macrophages
- Male
- Membrane Glycoproteins
- Mice
- Inbred C57BL
- Transgenic
- Oncostatin M
- Receptors
- Immunologic
- STAT5 Transcription Factor
- Signal Transduction
- Stem Cells
- TREM2
- hair cycle
- hair growth
… 외 2개
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
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