Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.
4/5 보강
TL;DR
How different SCs respond and adapt to a new environment is revealed, potentially explaining cellular plasticity of many epithelial tissues.
📑 코퍼스 인용 관계
· 인용됨 20
📑 인용한 논문 (6) ▾
- Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connectiv… Nature communications · 2026
- Autografted hair follicles with dermal papilla removed promote wound repair and regenerati… Journal of molecular histology · 2025
- Hair follicle punch grafts in hard-to-heal wounds: A monocenter study and patient survey. Health science reports · 2024
- Optimized Depilation Method and Comparative Analysis of Hair Growth Cycle in Mouse Strains… Animals : an open access journal from MDPI · 2024
- Materials-based hair follicle engineering: Basic components and recent advances. Materials today. Bio · 2024
- Construction of regulatory network for alopecia areata progression and identification of i… Precision clinical medicine · 2023
연도별 인용 (2018–2026) · 합계 204
OpenAlex 토픽 ·
Wound Healing and Treatments
Mesenchymal stem cell research
Hair Growth and Disorders
Abstract 🌐 Abstract
Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair follicle bulge and interfollicular epidermis (IFE), respectively, and monitored their individual transcriptional adaptations during wound healing using single-cell transcriptomics. Both Lgr5 and Lgr6 progeny rapidly induced a genetic wound signature that, for Lgr5 progeny, included the remodeling of receptors to permit interactions with the wound environment, a property that Lgr6 progeny possessed even before wounding. When contributing to re-epithelialization, Lgr5 progeny gradually replaced their bulge identity with an IFE identity, and this process started already before Lgr5 progeny left the bulge. Altogether, this study reveals how different SCs respond and adapt to a new environment, potentially explaining cellular plasticity of many epithelial tissues.
How different SCs respond and adapt to a new environment is revealed, potentially explaining cellular plasticity of many epithelial tissues.
APA 7
Joost, S., Jacob, T., Sun, X., Annusver, K., G, L. M., Sur, I., & Kasper, M. (2018). Single-cell transcriptomics of traced epidermal and hair follicle stem cells reveals rapid adaptations during wound healing.. Cell reports, 25(3), 585-597.e7. https://doi.org/10.1016/j.celrep.2018.09.059
Vancouver
Joost S, Jacob T, Sun X, Annusver K, G LM, Sur I, et al. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing. Cell reports. 2018;25(3):585-597.e7. doi:10.1016/j.celrep.2018.09.059
AMA 11
Joost S, Jacob T, Sun X, Annusver K, G LM, Sur I, et al. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing. Cell reports. 2018;25(3):585-597.e7. doi:10.1016/j.celrep.2018.09.059
Chicago
Joost, S., Jacob, T., Sun, X., Annusver, K., G, L. M., Sur, I., and Kasper, M.. 2018. "Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing." Cell reports 25 (3): 585-597.e7. https://doi.org/10.1016/j.celrep.2018.09.059
MLA 9
Joost, S., et al. "Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing." Cell reports, vol. 25, no. 3, 2018, pp. 585-597.e7. doi:10.1016/j.celrep.2018.09.059.
PMID
30332640 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- Cell Proliferation
- Cells
- Cultured
- Epidermis
- Female
- Hair Follicle
- Humans
- Mice
- Inbred C57BL
- Knockout
- Re-Epithelialization
- Receptors
- G-Protein-Coupled
- Single-Cell Analysis
- Skin
- Stem Cells
- Transcriptome
- Wound Healing
- Lgr5 stem cells
- Lgr6 stem cells
- RNA sequencing
- cellular plasticity
- computational analysis
… 외 5개
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
- A systematic summary of survival and death signalling during the life of hair follicle stem cells.
- Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis.
- Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after w…
- Signalling by senescent melanocytes hyperactivates hair growth.
- Coordinated hedgehog signaling induces new hair follicles in adult skin.
- Construction of regulatory network for alopecia areata progression and identification of immune moni…
- Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization.
- Molecular and spatial landmarks of early mouse skin development.
- Materials-based hair follicle engineering: Basic components and recent advances.
- Plasticity of Epithelial Cells during Skin Wound Healing.
- LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and …
- Optimized Depilation Method and Comparative Analysis of Hair Growth Cycle in Mouse Strains.
- Hair follicle punch grafts in hard-to-heal wounds: A monocenter study and patient survey.
- Diverse cellular players orchestrate regeneration after wounding.
- Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue s…
- Autografted hair follicles with dermal papilla removed promote wound repair and regeneration in Bama…
- Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration.
- New insights into inflammatory memory of epidermal stem cells.
- [Clinical effects of follicle unit extraction transplantation combined with recombinant bovine basic…
- Advances in resolving the heterogeneity and dynamics of keratinocyte differentiation.
같은 제1저자의 인용 많은 논문 (2)
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
-
Alopecia areata.
TL;DRAlopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the…
-
Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
TL;DRAlthough a variety of medical, surgical, light‐based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select ap…
-
Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…
-
Alopecia areata: A multifactorial autoimmune condition.
TL;DRVarious genetic and environmental factors that cause autoimmunity are discussed and the immune mechanisms that lead to hair loss in alopecia areata patients are described.
-
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.
TL;DRThe first meta-analysis of research on AA is performed by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a to…